Glucose intolerance, diabetes and coronary heart disease

Glucose intolerance and diabetes associated with the risk of fatal CHD

Dutch men aged 50-69 with glucose intolerance at entry, followed for 15 years, had a 2-fold greater risk of fatal CHD compared to men with normal glucose tolerance. A similar result was obtained for men who entered the study with clinical diabetes.

Glucose testing

In 1970 in the Zutphen Study, a glucose tolerance test was carried out with an oral load of 50 g glucose. Blood samples were taken after 30, 60, 120 and 150 minutes. The area under the curve of glucose values was calculated and ‘glucose intolerance’ was based on values above the median.

References

Feskens and Kromhout J Clin Epidemiol 1992;45:1327-34

From 1984 onwards, additional studies started to examine indicators of healthy ageing in the elderly populations of in the SCS and related studies.

Physical activity, APOE4 genotype and cognitive decline

Physical activity reduces the risk of stroke and may subsequently diminish the risk of cognitive decline, but changing the level of activity is more influential than maintaining it.

Depressive symptoms and cardiovascular disease

Depressive symptoms related to CVD mortality Elderly men from the FINE study cohorts of Finland, the Netherlands and Italy who manifested a number of [...]

Telomeres and all-cause mortality

Longer telomeres at baseline did not predict all-cause mortality, even though telomere shortening is a marker of aging that might be related to oxidative stress.

Optimism and depressive symptoms

The results suggest that optimistic elderly men are at a lower risk to develop depressive symptoms.

Glucose intolerance, diabetes and coronary heart disease

In men aged 50-69 a high glucose tolerance was, when compared to a low one, associated with a doubled risk of fatal CHD.

Glucose tolerance, diabetes at entry and all-cause mortality in elderly men

The relationship of glucose tolerance at entry with 5-year all-cause mortality was investigated in Finland in men aged 65-84. Impaired compared to normal glucose [...]

Physical activity, smoking, insulin, glucose tolerance and diabetes in non-diabetic Dutch men

In 1990 in the Zutphen Elderly Study habitual physical activity of leisure-time was assessed with a validated questionnaire. On average, the men spent 1.5 [...]

Diet, insulin and glucose tolerance in non-diabetic men in The Netherlands

In 1990 a cross-sectional survey was carried out on diet in relation to insulin in the Zutphen Elderly Study. The individual association of dietary [...]